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KMID : 1149220180260040319
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Korean Journal of Oriental Medical Prescription
2018 Volume.26 No. 4 p.319 ~ p.327
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Components of Astragali Radix at Various Ages and Their Effects of Physiological Activity
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Lee Jang-Cheon
Sung Dae-Dong
Ha Woo-Ram
Lee Boo-Kyun
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Abstract
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Objectives : Astragali Radix is known as a perennial plant, and it is estimated that there may be differences in the contents and their components depending on the ages. The components of astragali radix may activate differently.
Methods : The astragali radix components cultivated in Jecheon( one year ), Korea, Shanxi province( 7 years ), China, Inner Mongolia( 5 years) and Inner Mongolia ( 8 years ) were extracted with pure ethyl alcohol and identified the component molecules. The extracted components of astragali radix were measured the activity of Telomerase for confirmation of their Telomere lengths.
Results : The cell activity has been shown the greatest contribution in astragali radix of Inner Mongolia(8 years). Although there is the difference in cell activity between the two products of the 5 and 7 years, the difference between the values was small and the 7 years product was slightly higher than 5 years product.
Conclusions : Total Astragaloside contents were highest in the product of Inner Mongolia(8 years), followed by the 7 year product of Shanxi province. Especially, astragaloside and cycloastragenol (TA-65) among the astragali radix components have shown to be increased Telomerase activity in the DNA metabolism of the cells, and the efficacy depends on the ages of growth.
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KEYWORD
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Astragali Radix, Telomerase, Telomere lengths
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